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To discover potential changes in gene expression associated with suicidal thoughts, researchers looked at a group of 75 men they were already following as part of a longitudinal study on bipolar disorder. Over the course of multiple lab visits, nine of the men went from having no sign of suicidal thoughts at all to having significant suicidal thoughts. By looking at what changed in their blood and comparing it to the blood of demographically similar men who died from suicide, the researchers were able to pinpoint six likely biomarkers.
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