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    • 情報更新日:2021/05/27 13:05:57

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The researchers discovered that the cat dander protein Fel d 1 does not directly activate the immune system. Instead it must bind to the bacterial surface molecule LPS. LPS in turn is recognised by TLR4, which kicks off a signalling cascade, ultimately leading to a (sometimes severe) immune response. The researchers found this only occurs in the presence of an additional protein called MD2, which binds LPS to TLR4.

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